Apoptosis en el cancer pdf

Abnormalities in apoptotic function contribute to both the pathogenesis of colorectal cancer. Pdf apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. Given the dire effects of caspase activation, it is necessary that these two pathways remain closely regulated at each step. In addition, many apoptosisinducing drugs are currently being. The role of apoptosis in cancer development and treatment. It is used, in contrast to necrosis, to describe the situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Damage to dna can render a cell useless, or even harmful to an organism.

Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies. Apoptosis, the morphologically defined form of programmed cell death, is a cellular process that is of tremendous current interest to clinicians who study and treat cancer. The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. Apoptosis, cancer, via intrinseca, via extrinseca, resistencia a tratamiento, bcl 2, apo2ltrail. Necroptosis is a regulated necrotic cell death modality in a caspaseindependent fashion and is mainly. Ever since apoptosis was described by kerr et al in the. Normalmente, cuando algo va mal en una celula, esta es rapidamente destruida por apoptosis. Apoptosis is the programmed cell death which maintains the healthy survivaldeath balance in metazoan cells. Apoptosis, autophagy, necroptosis, and cancer metastasis. The term apoptosis is derived from the greek words and meaning dropping off and refers to the falling of leaves from trees in autumn. To gain insight into the functional status of the apoptosome apparatus in nonsmall cell. The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis.

These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal dna fragmentation, and global vague mrna decay. This results in tumor cells that are resistant to any intrinsic apoptotic stimuli which includes some anticancer drugs 2. The intrinsic apoptosis pathway represents an important mechanism of stressinduced death of cancer cells. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. The role of necroptosis in cancer biology and therapy. Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation of the extracellular matrix ecm, the epithelialtomesenchymal transition emt, tumor angiogenesis, the development of an inflammatory tumor microenvironment, and defects in programmed cell death.

Apoptosis and colorectal cancer pubmed central pmc. Apoptosis, or programmed cell death, evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells. Biochemical events lead to characteristic cell changes and death. Apoptosis and molecular targeting therapy in cancer. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases.