Apoptosis en el cancer pdf

Biochemical events lead to characteristic cell changes and death. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. Pdf apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal dna fragmentation, and global vague mrna decay. Apoptosis, autophagy, necroptosis, and cancer metastasis. Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation of the extracellular matrix ecm, the epithelialtomesenchymal transition emt, tumor angiogenesis, the development of an inflammatory tumor microenvironment, and defects in programmed cell death. Ever since apoptosis was described by kerr et al in the. Abnormalities in apoptotic function contribute to both the pathogenesis of colorectal cancer. Apoptosis and molecular targeting therapy in cancer. Apoptosis, or programmed cell death, evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells. The inactivation of programmed cell death, or apoptosis, is central to the development of cancer.

It is used, in contrast to necrosis, to describe the situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Necroptosis is a regulated necrotic cell death modality in a caspaseindependent fashion and is mainly. Apoptosis, the morphologically defined form of programmed cell death, is a cellular process that is of tremendous current interest to clinicians who study and treat cancer. The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis. To gain insight into the functional status of the apoptosome apparatus in nonsmall cell. Apoptosis and colorectal cancer pubmed central pmc. Defect in apoptosis can cause cancer or autoimmunity, while enhanced apoptosis may cause degenerative diseases. The role of necroptosis in cancer biology and therapy. In addition, many apoptosisinducing drugs are currently being. The term apoptosis is derived from the greek words and meaning dropping off and refers to the falling of leaves from trees in autumn.

Normalmente, cuando algo va mal en una celula, esta es rapidamente destruida por apoptosis. Apoptosis is the programmed cell death which maintains the healthy survivaldeath balance in metazoan cells. This results in tumor cells that are resistant to any intrinsic apoptotic stimuli which includes some anticancer drugs 2. This disabling of apoptotic responses might be a major contributor both to treatment resistance. It is also one of the most studied topics among cell biologists.

The intrinsic apoptosis pathway represents an important mechanism of stressinduced death of cancer cells. The role of apoptosis in cancer development and treatment. Apoptosis, cancer, via intrinseca, via extrinseca, resistencia a tratamiento, bcl 2, apo2ltrail. Chemotherapy drugs and radiation work by forcing the cancer cells to undergo apoptosis, triggering death signals by causing dna damage or cellular distress. Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Damage to dna can render a cell useless, or even harmful to an organism. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem.