Apoptosis en el cancer pdf

The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. Chemotherapy drugs and radiation work by forcing the cancer cells to undergo apoptosis, triggering death signals by causing dna damage or cellular distress. It is also one of the most studied topics among cell biologists. Apoptosis, the morphologically defined form of programmed cell death, is a cellular process that is of tremendous current interest to clinicians who study and treat cancer. The term apoptosis is derived from the greek words and meaning dropping off and refers to the falling of leaves from trees in autumn. Necroptosis is a regulated necrotic cell death modality in a caspaseindependent fashion and is mainly. Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation of the extracellular matrix ecm, the epithelialtomesenchymal transition emt, tumor angiogenesis, the development of an inflammatory tumor microenvironment, and defects in programmed cell death.

Damage to dna can render a cell useless, or even harmful to an organism. This disabling of apoptotic responses might be a major contributor both to treatment resistance. Apoptosis, or programmed cell death, evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells. Pdf apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. Normalmente, cuando algo va mal en una celula, esta es rapidamente destruida por apoptosis. Apoptosis, autophagy, necroptosis, and cancer metastasis. Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis. To gain insight into the functional status of the apoptosome apparatus in nonsmall cell. Biochemical events lead to characteristic cell changes and death. Abnormalities in apoptotic function contribute to both the pathogenesis of colorectal cancer. Apoptosis and molecular targeting therapy in cancer.

Apoptosis is the programmed cell death which maintains the healthy survivaldeath balance in metazoan cells. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem. This results in tumor cells that are resistant to any intrinsic apoptotic stimuli which includes some anticancer drugs 2. Apoptosis, cancer, via intrinseca, via extrinseca, resistencia a tratamiento, bcl 2, apo2ltrail.

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. Defect in apoptosis can cause cancer or autoimmunity, while enhanced apoptosis may cause degenerative diseases. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal dna fragmentation, and global vague mrna decay. Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies.